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This paper will explore early Greek scientific accounts about blood and magic regarding the nature of the account and a critical appraisal of such. The approach will combine medical history and philosophy of science. It will be the contention of this essay that in this early period there is a transition from explanations weighted heavily upon magic and the divine to those that are more materially based. The treatment of ‘blood’ is used to observe this transition. Some modern analogues are also noted.